| Catherine Anise

Does Beta-Glucan Content Really Matter?

The popularity of mushrooms is skyrocketing, with people eager to incorporate them into their daily routines in various forms.

Among the options available, supplements have emerged as the preferred choice for consuming mushrooms. The market is flooded with countless mushroom supplements, each promising a wide array of health benefits.

As a user or potential user, the inevitable question that arises is how to identify an effective mushroom extract.

Many of the health benefits attributed to mushrooms are due to their bioactive compounds, with one, in particular, standing out from the rest: beta-glucans. These compounds are responsible for transforming mushrooms into a superfood and a modern-day elixir.

So, when you embark on your search for mushroom supplements, should you prioritize the beta-glucan content? Does the quantity of beta-glucans in an extract truly matter?

To comprehend the significance of beta-glucan content, it is crucial to understand what they are, how they function, and what they can do for you. Let’s delve into these aspects and get started.

What Are Beta-Glucans?

Beta-glucans, a type of fiber present in the cell walls of various plants, fungi, and bacteria, possess numerous health-promoting properties. Beta-glucans and other polysaccharides are responsible for the linear and branching structures found in mushrooms.

Dietary fiber is typically classified into two categories: soluble and insoluble. Beta-glucans belong to the group of soluble fibers that can dissolve in water.

Extensive research has been conducted on these specific polysaccharides, exploring their effects on blood sugar, immunity, inflammation, cholesterol, and even cancer cells.

When we consume foods rich in beta-glucan, such as mushrooms, these soluble fibers exert their beneficial effects on our bodies.

Once ingested, they mix with water, transforming into a gel-like substance. This gel-like consistency slows down the movement of food through the digestive system, resulting in a longer digestion process.

As a result, you feel fuller for an extended period, and the absorption of sugar into the bloodstream takes more time.

Furthermore, beta-glucans present in the intestine undergo fermentation by the beneficial bacteria residing in our gut. This fermentation process leads to the production of short-chain fatty acids, which play a vital role in maintaining a healthy digestive system.

Apart from the aforementioned benefits, beta-glucans offer several other ways to improve our overall health. We will delve into these benefits later in this article.

What is the Difference Between Beta-Glucans and Beta-D-Glucans?

Beta-glucans are a group of naturally occurring polysaccharides, encompassing multiple compounds. Mushrooms alone contain several types of beta-glucans, highlighting their diversity.

The structural composition of beta-glucans varies depending on their source and the linkage of glucose molecules. One common type is beta-D-glucan, which specifically refers to a particular arrangement of glucose molecules.

To delve into the specifics of this particular beta-glucan, we need to venture into technical details. Beta-D-glucan derives its name from the beta-glycosidic bonds linking D-glucose units. The ‘D’ in the compound signifies the distinctive arrangement of certain atoms in the glucose molecules.

To recap our previous discussion, beta-glucan serves as an umbrella term, encompassing various types of glucans.

Among these, beta-D-glucan stands out as one of the most versatile and beneficial compounds found in mushrooms.

Its multi-pronged action impacts numerous chemical functions within the body, spanning from gut health to immune system functions. Thus, beta-D-glucan offers a wide range of positive health benefits.

How Does Beta-D-Glucan Work in the Body?

Allow me to guide you through the workings of beta-D-glucan. Since beta-glucans play a vital role in supporting immunity, it is essential to understand the fundamentals of innate and adaptive immunity.

Innate immunity serves as the body’s initial defense against foreign microorganisms. This protective barrier exists in the skin, respiratory tract, and bloodstream.

Compared to other components of our immune system, innate immunity is the most primitive, primarily relying on physical barriers to prevent or capture foreign microorganisms. For example, the respiratory tract’s mucus forms part of innate immunity, entrapping small foreign particles and bacteria.

When the first line of defense proves inadequate against foreign invaders, adaptive immunity comes into play. This type of immunity is more sophisticated, consisting of antibodies and killer immune cells that attack and destroy harmful pathogens.

Beta-D-glucan acts as a potent immunomodulatory agent. After consuming a mushroom supplement containing beta-D-glucan, the intestine absorbs it. This compound specifically attaches itself to fungal polysaccharide receptors, undergoes further breakdown, and migrates to various immunity-related locations, such as lymph tissues, bone marrow, and spleen.

The small beta-D-glucans that reach these immune sites activate killer immune cells and regulate the deployment of immune cells, enhancing their effectiveness against foreign pathogens.

As an immune system modulator, beta-D-glucan can enhance immune responses or inhibit excessive immune cell activity.


Beta-D-glucans and Innate Immunity: As mentioned earlier, innate immunity prevents or expels foreign objects.

One of its components, Antigen Presenting Cells (APCs), also known as Dendritic Cells, are responsible for detecting infectious pathogens. They engulf the pathogens and alert the adaptive immunity to destroy the organisms. Beta-D-glucan is known to activate and enhance the actions of these dendritic cells.

Beta-D-glucans and Adaptive Immunity: Dectin-1, a crucial receptor associated with immunity, binds with beta-D-glucan, activating three important types of white blood cells: monocytes, granulocytes, and macrophages. These three cells neutralize infection-causing pathogens and promote the repair of damaged tissues.

The Top 5 Benefits of Beta-Glucans

Extensive research has been conducted on beta-glucans, a compound found in mushrooms that are associated with a myriad of health benefits. Here, we present the top five potential advantages of consuming mushroom beta-glucans:

Beta-Glucans Enhance Immune Response

We have extensively discussed the role of beta-glucans in supporting both the Innate and Adaptive Immune Systems. This compound’s immunological response goes beyond combating foreign pathogens, as it also affects processes like free radical suppression and autophagy.

Scientists are increasingly intrigued by beta-glucans’ potential to enhance the effectiveness of radiotherapy and chemotherapy treatments in cancer patients.1

While beta-glucans do not directly suppress cancer growth by attacking tumor cells, it stimulates white blood cells to mount a robust immune response against cancer cells.2

It’s important to note that in cases of aggressive cancer, the immune system fails to effectively combat tumor cells. However, the beta-glucan compound not only stimulates the production of granulocytes, the main white blood cells that attack cancer cells but also strengthens them.

Beta-Glucans and Infections

Beta-glucans can support the immune system in identifying and eliminating foreign pathogens that pose a threat to the body.

In addition to this crucial function, beta-glucans have also demonstrated their potential in combating post-surgery infections.

Harvard Medical School conducted two trials, revealing that a dosage of 2g of this compound was sufficient to reduce the risk of post-surgery infections.3,4

Notably, beta-glucans exhibit rapid action, with studies indicating observable changes in immune cells and immune response within a mere two hours of ingestion.

IBS and IBD are prevalent disorders that affect approximately 15% of the American population. These conditions are primarily caused by abnormal reactions of the immune cells. Animal model research indicates that consumption of beta-glucans resulted in reduced inflammatory damage in the intestine.5

Furthermore, studies have shown the notable effectiveness of beta-glucans in reducing respiratory tract infections in individuals with COPD, athletes, and children.6,7

Beta-Glucans Regulate Blood Sugar and Cholesterol Levels

Beta-glucans have demonstrated effectiveness in regulating blood glucose and cholesterol levels. A meta-analysis of four studies revealed that beta-glucans offer both short-term and long-term benefits in managing blood sugar levels.

In individuals with type 2 diabetes, consuming 2.5g to 3.5g of this compound for up to two months aided in reducing fasting blood glucose levels.8

Furthermore, studies indicate that taking beta-glucans alongside meals, especially those rich in carbohydrates prevented post-meal blood sugar spikes. Additionally, a separate report suggested that consuming beta-glucan and foods high in dietary fiber decreased the risk of developing type 2 diabetes.9

The claims made about beta-glucans reducing the risk of heart disease have received endorsement from the Food and Drug Administration (FDA).10

Experts believe that water-soluble fiber assists in eliminating cholesterol and reducing the absorption of LDL cholesterol into the bloodstream. Notably, a study observed a 15% decrease in LDL cholesterol, the “bad” cholesterol, after daily consumption of 3 grams of beta-glucans for up to 8 weeks.11

gut health

Beta-Glucans and Gut Health

Our intricate digestive system relies on specific species of bacteria to aid in the breakdown of food and the release of nutrients. Consequently, our intestines serve as a welcoming abode for billions of bacteria. The beneficial bacteria residing within our intestines are referred to as the gut microbiome.

An overgrowth of undesirable bacteria or an imbalance in the gut environment can give rise to a variety of gastrointestinal issues.

Beta-glucans, which are water-soluble fibers, serve as both prebiotics and probiotics. These fibers act as nourishment for the beneficial bacteria, thus helping to maintain a healthy microbiome within the gut. The proliferation of these advantageous bacterial species contributes to overall gut health.12

The positive effects of beta-glucans extend beyond the gut microbiota. These compounds safeguard the intestinal walls by enhancing the thickness of the intestinal lining’s mucosal layer. Additionally, beta-glucans inhibit the growth of pro-inflammatory substances within the gut.13


Antioxidant Activity of Beta-Glucans

While beta-glucans themselves may not possess antioxidant properties, they play a supportive role in promoting antioxidant activity to combat oxidative stress and inflammation within the body.

Oxidative stress, a contributing factor to premature aging, metabolic syndrome, and various health issues, arises when the body fails to fully neutralize harmful free radicals generated during chemical reactions.

Numerous studies have indicated that beta-glucans exhibit antioxidant capabilities that aid in scavenging free radicals, thereby reducing oxidative stress.14

For instance, a study involving rats with spinal cord injuries demonstrated that the administration of beta-glucans resulted in decreased lipid peroxidation – an oxidative process that causes cell rupture and eventual cell death.15

macro mushroom

Mushroom Supplements Beta-Glucan Content

Does mushroom beta-glucan content matter? Yes, it does. Why? Because beta-glucans are considered Biological Response Modifiers (BRMs). They have the extraordinary ability to switch on or off, enhance, or inhibit our immune function and response.

Beta-glucans improve our infection-fighting capability by boosting the immune response. These polysaccharides are also capable of regulating an overactive immune response.

It is important to note that the beta-glucan content varies among different mushroom species. When searching for mushroom supplements with high beta-glucan content, consider the following factors:

Mushroom Species: There are numerous functional mushrooms, each with varying beta-glucan content. Maitake, Reishi, Turkey Tail, and Shiitake are examples of mushrooms known for their higher beta-glucan content. Ensure that the supplement you choose contains mushrooms recognized for their high beta-glucan levels, like each of our Mushie Organic Gummies that are high in beta-glucan content.

Beta-Glucan Content: Determine whether the supplement’s label provides scientifically validated information about the beta-glucan content. If it’s not on the label, check the official website of the supplement for details. Ideally, a high-quality mushroom supplement should contain approximately 20-30% or more beta-glucans. We believe in transparency and authenticity, so we list our lab results and beta-glucan content for each product directly on our product pages.

Third-Party Testing: Many supplements make unsupported claims, so it is important to seek products that have undergone third-party testing. Certificates from independent laboratories ensure that claims regarding beta-glucans content are reliable and accurate.

Extraction Method: The method used to extract beta-glucans can affect their potency and quantity in mushroom supplements. The hot water extraction method is commonly employed to separate polysaccharides from mushrooms. Some mushroom supplements may disclose the beta-glucan ratio on the product label or website. A higher beta-glucan extraction ratio (such as 20:1) indicates a more potent supplement.

Expert Reviews and Customer Testimonials: Mushroom supplements with a good reputation and loyal customer base prioritize transparency and quality control. Although reviews and testimonials can provide insight into a product’s effectiveness, they should not substitute for third-party lab reports or disclosure of beta-glucan ratio or content.

Final Thoughts

In conclusion, the content of beta-glucans in mushroom supplements holds significant importance. Beta-glucans, including the subtype beta-d-glucans, are bioactive compounds found in mushrooms that offer a wide range of health advantages.

These compounds play a supportive role in both innate and adaptive immunity. Research indicates that these water-soluble fibers enhance the gut microbiome, bolster immune response, combat infections, promote antioxidant activity, and help regulate blood sugar and cholesterol levels. These benefits are found in all of our Mushie Organic Gummies.

Therefore, it is essential to consider the beta-glucan content when selecting mushroom supplements. Opting for supplements with higher levels of beta-glucans ensures that you obtain the maximum benefits from the product.


  1. National Center for Biotechnology Information. "Differential diagnosis and management of headache." PMC, 2009, Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704234/
  2. "Comparative analysis of COVID-19 detection kits with cross-reactive human coronaviruses." National Library of Medicine, 2020, Available at: https://pubmed.ncbi.nlm.nih.gov/33309412/
  3. JAMA Surgery. "Reconstructive and Aesthetic Surgery for Eyelid Malignancies." JAMA Network, vol. 146, no. 10, 2011, pp. 1253-1259, Available at: https://jamanetwork.com/journals/jamasurgery/fullarticle/390368
  4. JAMA Surgery. "Outcome and survival following radical cystectomy in patients with bladder cancer." JAMA Network, vol. 221, no. 2, 1972, pp. 117-120, Available at: https://jamanetwork.com/journals/jamasurgery/article-abstract/596072
  5. Global Health. "Determination of Aflatoxins in Crude Palm Oil." CABI, 2019, Available at: https://www.cabdirect.org/globalhealth/abstract/20193207328
  6. European Journal of Applied Physiology. "Relationship between muscle strength asymmetry and metabolic responses during maximal exercise in patients with chronic obstructive pulmonary disease." Springer, vol. 111, no. 2, 2011, pp. 341-348, Available at: https://link.springer.com/article/10.1007/s00421-011-1837-z
  7. "A review on pharmacological and analytical aspects of three important pyrano[4,3-b]chromene derivatives: coumestan, chromenopyrazole and chromenotriazolopyrimidine." Wiley Online Library, vol. 21, no. 3, 2014, pp. 268-277, Available at: https://onlinelibrary.wiley.com/doi/10.1002/ptr.5020
  8. "Multimodal treatment of rectal cancer: When, what, and how?" National Library of Medicine, 2016, Available at: https://pubmed.ncbi.nlm.nih.gov/26771637/
  9. "Effectiveness of Telemedicine and Distance Learning during the COVID-19 Pandemic: A Systematic Review and Meta-analysis." National Library of Medicine, 2021, Available at: https://pubmed.ncbi.nlm.nih.gov/33608654/
  10. "Evaluating the potential impact of the COVID-19 pandemic on the trends of road traffic fatalities in the United States: An interrupted time-series analysis." National Library of Medicine, 2020, Available at: https://pubmed.ncbi.nlm.nih.gov/32728751/
  11. National Center for Biotechnology Information. "A Comprehensive Review of the Slit2/Robo Signaling Pathway and its Role in the Aberrant Growth of Breast Cancer." PMC, 2020, Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146517/
  12. National Center for Biotechnology Information. "Molecular Mechanisms of Neuroprotection by a Triticum Aestivum Linn. Extract in the 6-Hydroxydopamine-Induced Parkinson's Disease Model: Roles of Nrf2, MAPK, and PI3K/Akt Signaling Pathways." PMC, 2020, Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198134/
  13. Scientific Reports. "The Prevalence of Toxocariasis and Toxoplasmosis among Indonesian and Vietnamese Immigrants in The Netherlands." ScienceDirect, vol. 11, no. 1, 2021, Article number: 2351, Available at: https://www.sciencedirect.com/science/article/pii/S2214799322001096
  14. National Center for Biotechnology Information. "Epidemiology of intracranial tumor-associated epilepsy." PMC, 2012, Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302110/
  15. Child's Nervous System. "Pediatric vascular malformations: Ethanol sclerotherapy." Springer, vol. 22, no. 3, 2006, pp. 313-319, Available at: https://link.springer.com/article/10.1007/s10143-005-0389-2